CONSISE is in the process of developing seven standardized research protocols for influenza.

Standardized protocols for epidemic/pandemic influenza:

  • Protocol 1: Prospective longitudinal cohort study of influenza infection during epidemic periods
    • Primary Objective: Determine age specific cumulative incidence of infection during an influenza epidemic
  • Protocol 2: Cross sectional seroprevalence study of influenza prior and post epidemic periods
    • Primary Objectives: Determine age specific cumulative incidence of infection with a novel influenza virus in the population and Measure prevalence of cross-reactive antibodies to the novel
  • Protocol 3: Household transmission studies for pandemic influenza 
    • Primary Objectives: Estimate household secondary infection risk, and factors associated with variation in the secondary infection risk; Characterize secondary cases including clinical presentation and asymptomatic fraction; and  Investigate serological response following confirmed influenza infection
  • Protocol 4: Closed setting outbreak investigation protocol for pandemic influenza
    • Primary Objectives: Describe the clinical spectrum of infection including the asymptomatic fraction; Estimate overall clinical attack rates (by subgroup and clinical risk group); and Describe correlation between infection, disease and serology
  • Protocol 5: Assessment of health care personnel
    • Primary Objectives: Detect the presence of human-to-human transmission of a novel virus within a health care setting 

Standardized protocols for seasonal influenza:

  • Protocol 6: Seroepidemiology of human influenza infection using residual sera/convenience samples for establishing baselines and/or monitoring trends over time 
    • Primary Objectives: Estimate population immune status/susceptibility to relevant influenza viruses; Estimate incidence in previous-seasons for the different relevant influenza viruses

Standardized protocols for zoonotic influenza: