CONSISE and the Institut Pasteur were asked to draft six standardized research protocols for Zika. Our expertise in rapidly drafting such technical documents, summoning and incorporating technical input have allowed us to support efforts to harmonize epidemiologic and clinical research for Zika.

The six protocols (listed below) were developed by CONSISE and Institut Pasteur and have undergone significant technical review by research and public health professionals working on Zika and other arborviruses. We worked closely with WHO, affected coutnries in the Americas and Caribbean and ISARIC to draft and finalize the protocols. 

The protocols currently available include:

  • Case-control study to assess potential risk factors related to microcephaly caused by Zika virus infection
  • Case-control study to assess potential risk factors related to Guillain-Barré Syndrome caused by Zika virus infection
  • Prospective longitudinal cohort study of women and newborns expsed to ZIKV during pregnancy
  • Prospective longitudinal cohort study of newborns and infants born to mothers exposed to Zika virus during pregnancy
  • Cross-sectional seroprevalence study of Zika virus infection in the general population
  • Prospective longitudinal cohort study of Zika-infected patients to measure the persistence of Zika virus in body fluids

All protocols are currently undergoing ethical review by WHO and the first version of these protocols are now available on the WHO website: http://origin.who.int/reproductivehealth/zika/zika-virus-research-agenda/en/. For further information, please contact Maria Van Kerkhove (maria.van-kerkhove@pasteur.fr).

A seventh protocol (called the Clinical Characterization Protocol for Zika Virus Infection in the Context of Co-circulating Arborvirus) to better understand the natural history of ZIKV infection has been drafted by WHO, IDAMS and ISARIC.  THis protocol will also be available on the WHO website soon.

Read about the development of the ZIKV research protocols here: Van Kerkhove MD, Reveiz L, Souza JP, Jaenisch T, Carson G, Broutet N for the Working Group on ZIKV Harmonized Research.  Harmonization of Zika virus research protocols to address key public health questions.  Lancet Global Health. Published 1 November 2016.